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Off-label use in post-menopausal women is practiced by some clinicians, but the evidence base is thinner

NAC replenishes glutathione levels, avoiding irreparable damage [58]

Given that the PVN is a crucial brain region for sensing stress 51,52 , these findings could also explain that acute stress and chronic negative mood disorders cause disturbances in intestinal functions 53 , such as diarrhea and constipation 54,55

59 Thus, patients with MD often present with abnormalities in their connective tissue, including osteopenia, skin laxity, arterial aneurysms, and spontaneous fractures

Although most evidence remains correlative, the consistent findings across ethnically and geographically diverse cohorts underscore the clinical relevance of TMAO as a biomarker and potential therapeutic target in cardiovascular disease