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Importantly, the research group which developed GPNMB vaccines also reported that GPNMB is an important regulator of lysosomal activity, and that genetic depletion of GPNMB can lead to shortened replicative lifespan in vascular endothelial cells, vascular dysfunction and increased formation of atherosclerotic plaques, with its effect on other tissues and organs remaining unclear

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[DOI] [PubMed] [Google Scholar] 143.Milatz S, Piontek J, Hempel C, Meoli L, Grohe C, Fromm A, Lee IM, El-Athman R, Gunzel D