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Spine 47(11):E494-E498, 2022

Key challenges in oral delivery of cyclic peptides The poor oral bioavailability of cyclic peptides stems from numerous interdependent factors, including physicochemical constraints, gastrointestinal (GI) tract biology, enzymatic degradation, active efflux, and first-pass metabolism, which result in low and variable oral absorption: 1

As a result, recent efforts have focused on the outcomes of TDP-43 mislocalization as early markers of dysfunction and/or mechanisms driving disease

doi: 10.1006/bbrc.1995.1266 145 Timson GauenLKLinderMEShawAS

Expression of cyclooxygenase isoforms in normal human skin and chronic venous ulcers