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Subsequently, pyruvate, the end product of glycolysis, is transported into the mitochondria and oxidized by PDC to generate NADH and acetyl-CoA, the latter entering the TCA cycle

The redox balance depends on many parameters, including the levels and the compartmentalization of ROS, their specific sources and subspecies and the specificity/selectivity for their targets

Combined targeting of STAT3/NF-B/COX-2/EP4 for effective management of pancreatic cancer

Bioorg Med Chem Lett 21:42594262 Pacher P, Beckman JS, Liaudet L (2007) Nitric oxide and peroxynitrite in health and disease

It would be plausible to assume that altered glutaminergic signaling in these principal cortico-limbic circuits may be reflected in diverse bipolar clinical symptomatology

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