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Glutathione peroxidase 4, heat shock protein beta-1, and nuclear factor erythroid 2-related factor 2 function as negative regulators of ferroptosis by limiting ROS production and reducing cellular iron uptake, respectively

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As a consequence of low glutathione and the lack of negative feedback, an increase of -glutamyl-cysteine production takes place

Because of TQs propensity to react with thiol-rich proteins and modulate powerful antioxidant enzymes like GSH, it is bundled with an exclusive group of therapeutic drugs called Michael reaction acceptors (308) that are associated with safeguarding overall cellular health (239, 309) and is a natural activator of Nrf2 signaling

Therefore, the concentrations of the analyzed compounds may vary, and more information about the impact of the habitat on the tested taxon can be obtained by studying a few organisms from one habitat

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