glutathione s-transferase pi gstp function S‐transferase‐Pi 1 protects cells from irradiation‐induced death by inhibiting ferroptosis in pancreatic cancer - Zhu - 2024 - The FASEB Journal Glutathione S-Transferase pi 1/GSTP1 Antibody

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NRF2 also modulates inflammatory responses by inhibiting pro-inflammatory genes and mediates cell death pathways, including apoptosis and ferroptosis

29 The reason for this difference is not apparent apart from the fact that H 2 O 2 levels were measured in young SHR and in whole kidney homogenates in this study, whereas in the above studies measurements were made in cells in vitro

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It catalyzes the first step of glutathione synthesis, which consumes one molecule of ATP and combines glutamate and cysteine to form -glutamylcysteine (-Glu-Cys)

These discoveries underscore the clinical importance of USP43 in epithelial ovarian cancer, accentuating its potential as a therapeutic target to manage cancer progression, increase sensitivity to cisplatin chemotherapy, and ultimately enhance patient outcomes [309]