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Methods: Sixty four cirrhotic patients with advanced HCC (56 males, mean age 67 years, 22 with diabetes, CPT-A=45/B=19, mean MELD-Na=11, ALBI grade I=20/grade II=38, 28 with varices, 18 with extrahepatic disease, 24 with macrovascular invasion) who either initially presented in the BCLC-C stage and were treated with ATZ/BEV (group A, N=23) or TKIs (group B, N=15) or who migrated from BCLC-A to BCLC-C within 2 years after LR or RFA and were treated with ATZ/BEV (group C, N=12) or TKIs (group D, N=14) were evaluated

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Mechanism of Action Mechanism of Action Copper Transport & "Redox Silencing" GHK-Cu acts as a carrier peptide with high affinity for copper(II) ions (pKa = 16.44)

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The safety and tolerability of AMX0035 had been previously confirmed in small PALS trials