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At the methodological level, isotope tracing technologies can directly resolve actual metabolic flux changes, single-cell and spatial multi-omics can help identify cell-cell interactions and substrate competition in the tissue microenvironment, and genome-scale metabolic modeling can be used for priority ranking and assessment of targetability

In addition to mitochondrial dysfunction, lipid dysregulation is another hallmark of ALS pathology (Abdel-Khalik et al., 2017)

Current research has not yet fully elucidated why TINs exhibit both susceptibility and resistance to ferroptosis across different tumor types or even within the same tumor model

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Binding of AngII to its AT1 receptor leads to the activation of MAP kinases, phosphorylation of tyrosine kinases and production of ROS, all of which induce VSMC proliferation

A metal-sensitized sonocatalyst idea has been presented to tackle these issues, wherein noble metals augment the sonocatalytic efficacy of semiconductors