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4b,c and Extended Data Fig

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Cortical ERK was demonstrated to be erroneously deactivated following mGluR stimulation in Fmr1 /y mice (Kim et al., 2008), whereas it was illustrated to be normal (Osterweil et al., 2010) or even over-activated in hippocampal tissue (Hou et al., 2006

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[34] The CLK/CYC loop occurs during the day in which both Clock protein and cycle protein are produced