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doi: 10.12659/MSM.946512

Although a plethora of tumor cell mechanosensors have been identified, including focal adhesions, ion channels, actin cytoskeleton, nuclear proteins, and transcription factors, more research is needed to uncover how breast cancer cells convert biophysical signals into biochemical cues to mediate short- and long-term mechanoresponses ( Table 5 )

Some studies suggest that supraphysiologic doses shift the collagen ratio toward type III, a weaker form associated with immature or healing tissue

Hsu A, Frank SJ, Ballo MT, Garden AS, Morrison WH, Rosenthal DI , Hatef E, Esmaeli B

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