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In addition, as the global population ages, the societal and economic impact of age-related macular degeneration is poised to increase

doi: 10.1177/23247096211042236

4,719,201, it is disclosed that when ATP is hydrolyzed to AMP in cardiac muscle during ischemia, the AMP is further metabolized to adenosine, inosine and hypoxanthine, which are lost from the cell upon reperfusion

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