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in rodent animals

Production of nitric oxide by glial cells: regulation and potential roles in the CNS

4.2.5 Oxidative stress and inflammatory response An increased abundance of Gram-negative bacteria in the gut of PCOS patients elevates circulating LPS, which activates the LPS/TLR4 pathway and sustains systemic chronic low-grade inflammation (73)

Paracrine GABA-mediated regulation (as described above) is suggested by the finding that isolated rat alpha cells no longer show reduced glucagon/glutamate release at elevated glucose concentrations [112], and the observation that in rat islets and purified alpha cells, GABA antagonists suppress glucagon secretion [114]