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There is also a growing appreciation for an association between NAFLD/NASH and ferroptosis, the process of iron-dependent regulated cell death (Tsurusaki et al., 2019

Endogenous mitochondrial oxidative stress: neurodegeneration, proteomic analysis, specific respiratory chain defects, and ef!cacious antioxidant therapy in superoxide dismutase 2 null mice

mTOR: Mammalian target of rapamycin

Meanwhile, the genes related to fatty acid biosynthesis are significantly downregulated

S-nitrosylation involves the transfer of NO to one or more cysteine thiol groups and it occurs when there is an increased production of RNS during oxidative stress (Conway and Harris, 2015)