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vWF is stored in WeibelPalade bodies within endothelial cells and is rapidly secreted into the circulation following endothelial activation or damage, where it mediates platelet adhesion and forms high-molecular-weight multimers associated with pathological thrombosis (Lodigiani et al., 2020)

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Since 2010, it has technically remained the only truly FDA-approved treatment specifically indicated for the treatment of chronic migraine prevention, up until Qulipta (Atogepant) became the first and only pill to receive FDA approval for chronic migraine in 2023

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