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Future investigational priorities should encompass: (1) rigorously designed pharmacokinetic evaluations examining standardized polyphenolic extract effects on SGLT2 inhibitor plasma kinetics

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Concurrently, hyperphosphorylation and its abnormal accumulation, coupled with impaired clearance, lead to the formation of NFTs, further compromising neuronal function

Children and adolescents may also be diagnosed with localized HSD (L-HSD) or peripheral HSD (P-HSD) if they have joint hypermobility in specific areas rather than throughout the body

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