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Additionally, a comprehensive understanding of the roles of glial cells in glutamate excitotoxicity may pave the way for new therapeutic approaches and strategies to treat many brain pathologies, such as ischemia or Alzheimers and Parkinsons disease, amyotrophic lateral sclerosis or even psychiatric disorders, for example, schizophrenia

Bucko, P

Co-treatment with a specific inhibitor of the lactate/H + transporter MCT1, AZD3965, led to increased apoptosis in APAP-treated cells, suggesting that lactate accumulation could be a cause of cell death in this model

30 , 969983.e4 (2020)

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doi: 10.1016/j.tcb.2023.06.002 6 LiuYLuSWuLYangLYangLWangJ