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Description

Effects were quantified and expressed by the x -fold change method calculated as: mean CQ (quantification cycle) gene mean CQ housekeeping gene dCQ and fold = 2 dCQ

GOLD was used to dock T1 , T2 , T3 and T5 into the active site of the X-ray (PDB ID: 2Y9X) and a human tyrosinase model (built by Multiple sequences alignment and Homology modeling of Discovery Studio v.4.0 using the structure of mushroom tyrosinase as a template (PDB ID: 2Y9X) (Supplementary Fig