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Both RFK and FLAD1 reside in the cytosol and within mitochondria, allowing newly formed FAD to accumulate in the mitochondrial matrix, where it serves as an essential co-factor for numerous flavoproteinsincluding ETF-DH, AIFM1, multiple acyl-CoA dehydrogenases, and glutathione reductase (Figure 1) (60)

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Further clinical studies are warranted in order to confirm and compare the effects of the studied agents, sesamol and astaxanthin, with those of conventional therapies on human, especially on longer durations

Discontinue at least 2 months before a planned pregnancy