l carnitine peripheral artery disease L-Carnitine | Linus Pauling Institute Atherosclerosis | Linus Pauling Institute

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This process, which ensures an adequate supply of free CoA, is essential for the oxidation of pyruvate and helps to coordinate pyruvate dehydrogenase activity with the rate of glycolysis, thereby maintaining the bodys ability to switch between fat and carbohydrate as the main energy substrate [9]

However, skeletal muscle-specific carnitine palmitoyltransferase 2 (CPT2)-deficient mice accumulate large amounts of acylcarnitine in muscle and plasma and still preserve insulin sensitivity [75], highlighting the role of acylcarnitine only as an indicator of FAO rather than as a direct mediator of insulin resistance [76]

Abell TL, Adams KA, Boles RG, et al

Brando P, Gonalves-Henriques M, Ceschin N

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