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According to the latest EASL Clinical Practice Guidelines, non-invasive scores, serum markers, liver stiffness and imaging methods should be used for ruling out rather than diagnosing advanced fibrosis in low-prevalence populations and should be preferentially employed in patients at risk of advanced liver fibrosis (63)

[50,51] Potential biologics have been generated to target pro-inflammatory cytokines, such as IL-1, interferon (IFN)-, IFN-, IL-6, TNF-, IL-17, and IL-21, and several clinical trials that aim at inhibiting the activities of these mediators have been initiated

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Altered functional connectivity between the amygdala and vmPFC neural circuit is also observed in rodents after traumatic events, leading to the pathophysiology of PTSD (Liang et al., 2014)

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