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Despite there is no consensus on regarding the features a binding site must have to be druggable, some authors may argue that features like hydrophobicity, shape, size, or even the combination of them are pivotal to make a site druggable 101,102,103

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Liver failure after transarterial chemoembolization for patients with hepatocellular carcinoma and ascites: incidence, risk factors, and prognostic prediction

TABLE 1 Key amino acids of FXN identified as impaired variants