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& Busch, K

Yet, up to one third of community-dwelling older adults that display significant AD-like neuropathology post-mortem experience negligible reported cognitive decline in life 2,3

Pashaj A, Yi X, Xia M, Canny S, Riethoven JJ, Moreau R

Beyond SCFAs, arginine reinforces CD8 + T cell activity and inhibits Tregs via mTOR signaling (77), whereas Trp metabolites exhibit divergent effects: Kyn induces CD8 + T cell exhaustion through AhR-dependent programmed death-1 (PD-1) upregulation (78), contrasting with DATs enhancement of IFN-I-primed T cell expansion (79), and LPS exhibits dose-dependent immunomodulation, acutely activating T cells before promoting exhaustion during chronic exposure (80)

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Men received a placebo or an antioxidant supplement comprising of vitamins C, E, D, selenium, L-carnitine, zinc, folic acid and lycopene from three to six months [37]