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Current treatments targeting single inflammatory mediators may have limited efficacy due to redundancy within the innate immune system and the potential for eventual immunosuppression

As a principal transcription factor, T-bet predominantly localizes to the nucleus, where it orchestrates the regulation of gene expression ( Figures 1B, C )

Clin Exp Hypertens 2005

Supplementary Table S3 summarizes the proteomic methodologies discussed, highlighting their principles and applications in CF oxidative stress research

The mediators of cartilage damage include MMPs, a disintegrin-like metalloprotease with thrombospondin type 1 motifs 4 and 5 and cathepsins