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Additionally, the triglyceride-glucose (TyG) index, a measure of the relationship between fasting plasma TG and glucose levels (259, 260), was independently linked to a higher prevalence of depression among T2DM patients, as reported by Jiaju Ren et al

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Therefore, better understanding of the mechanism underlying the pathological activation of NF-B in individual diseases is crucial for designing more specific and effective therapeutic agents for the treatment of inflammatory diseases

The fundamental difference relative to apoptosis is the rapid loss of cellular membrane potentials due to energy depletion and ion pump/channel failures, leading to swelling, rupture, and cytolysis

However, due to the added effect of electrostatic attraction, it is theoretically possible for the cation to be more toxic and more bioaccumulative