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Dose adjustments should be rare after reaching maintenance and based on specific clinical indicators rather than impatience with plateau timing

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400,401 UPS-targeted therapies in NDDs Proteasome activation The ubiquitinproteasome system plays a central role in clearing misfolded and damaged proteins, and its dysfunction contributes directly to protein aggregation in NDDs

Integration of network pharmacology and untargeted metabolomics reveals Changpu Sans antidepressant mechanisms via tryptophan metabolism

Notch pathway up-regulation via curcumin mitigates bisphenol-A (BPA) induced alterations in hippocampal oligodendrogenesis