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This proliferative halt may indirectly reduce basal levels of cellular anabolism and reactive oxygen species (ROS) generation, thereby enhancing resistance to ferroptosis (108)

Med 321 , 17071713 (1989)

Kessing LV, Vradi E, Andersen PK

The reaction formula can be summarized as follows: 2 GSH GSSG + 2H + 2e (under the action of GPX or ROS) However, to prevent GSSG accumulation from disrupting the intracellular sulfhydryl balance, cells need to rapidly convert it back to GSH through an efficient reduction system

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