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Its contribution to weight loss is less straightforward than GLP-1's and is still an active area of research, but targeting both receptors simultaneously appears to produce greater weight reduction than GLP-1 alone, which is the basis for tirzepatide's dual mechanism

Its influence on the brain-gut axis is also a significant area of investigation

Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA: Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone in healthy adults

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(1999) provided a comprehensive review of these gastroprotective findings, documenting consistent results across more than 20 distinct experimental lesion models (Sikiric et al., 1999, Journal of Physiology Paris

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