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One of the main molecular pathologic mechanisms in this setting is represented by -synuclein aggregation in mitochondria, which leads to the production of reactive oxygen species (ROS) and induces activation of p38 MAPK, a MAP-kinase that triggers the phosphorylation of Drp1 (dynamin-related protein-1), which eventually leads to mitochondrial fission (Martin et al., 2014)

doi: 10.1124/jpet.112.192138 11 ZhangHChenYWangZXieGLiuMYuanBet al

Conclusion : SAG has more preclinical data supporting liver protection, especially in anti-inflammation and antioxidant pathway activation

EGCG protects against corticosterone-induced neuron damage by regenerating the PI3K/AKT and ERK1/2 pathways

Different authors have used biophysical assays to study the interaction between oleuropein and membrane lipids [61]

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