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Histological assays showed a lack of severe immune-cell infiltration in the liver of hepsin / mice compared to wild-type mice within 6 h post-APAP exposure, suggesting the need for further investigation of inflammation in hepsin-mediated APAP intoxication

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There is an urgent need for national surveillance, child-specific risk assessments, stronger food safety enforcement, and public health education to mitigate exposure and protect vulnerable populations

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Hamaguchi T, Ono K, Murase A, Yamada M

Luzindole (LUZ) is a widely used non-selective antagonist of the melatonin receptors MT1 and MT2, enabling us to test whether the effects of exogenous melatonin were receptor-mediated ( Figure 2 Using the same multi-parameter approach applied to the AA model, we evaluated disease outcomes in IL-33 challenged mice in the presence or absence of melatonin and Luzindole