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The importance of zinc homeostasis is highlighted by the remarkable number of diseases associated with alterations in tissue zinc levels, which is summarized in Figure 1 (right hand side)

No tolerance developed to this protective effect, which appeared to be mediated by (1) the activation of 5-HT 1A receptors, as it was antagonized by the administration of WAY100635 30 min before stress exposure

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Therefore, the GPx-like catalytic activity of compounds was studied using glutathione (GSH) as thiol cofactor and hydrogen peroxide (H 2 O 2 ) as substrate [57, 58]

359 Shikonins dual inhibition of TRXR and PKM2 induces necroptosis, whereas Nrf2 hyperactivation mediates resistance, which can be reversed through metabolic targeting

13,28 In fact, the average time between seeking care and getting a fibromyalgia diagnosis has been reported to be 2.7 years