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Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 Degron and the Redox-insensitive Neh6 Degron

Additionally, butyrate regulates gut immune cell function by inhibiting histone deacetylase (HDAC) activity, promoting the differentiation of Treg, and suppressing the release of pro-inflammatory cytokines such as IL-6 and TNF-, thereby alleviating intestinal inflammation [439, 440]

It helps replenish fluids lost during sleep, supports metabolism, and prepares the digestive tract for food intake

Increasing evidence suggests that macrophage polarization and ferroptosis can influence each other at the cell level independently or through interactions with other cells in a context-dependent manner

Thus, although there is no direct contact between NS5B and D1467, the D1467G mutation may alter the NS3hNS5B interaction by weakening long-range electrostatic interactions

These findings illuminate the potential for targeting this pathway to improve regenerative outcomes