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Nat Rev Gastroenterol Hepatol 6(5):306314

doi: 10.1158/0008-5472.CAN-18-1010 10 AlhalabiOZhuYHamzaAQiaoWLinYWangRMet al

383,384 Importantly, the activation of AMPK reduces the expression of phosphoglycerate mutase 5 (PGAM5), which plays a promotive role in cell necrosis by contributing to mitochondrial dysfunction and the production of reactive oxygen species (ROS)