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Clinical signs of toxicity at the 800 mg/kg dose level included trembling in both species, ataxia in rats, and pale skin colour in mice

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[151] Pigatto PD, Minoia C, Ronchi A, Brambilla L, Ferrucci SM, Spadari F, Passoni M, Somalvico F, Bombeccari GP, Guzzi G

Bromelain-NPs possibly acted by maintaining a balance between the positive and negative regulators of apoptosis and triggering more cells to apoptosis than free bromelain

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