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10.1038/s41418-018-0126-3 36 HanS.ShinH.LeeJ

J.PruvostC.PolleA.FoyerC

Protein levels of HIF-1 are increased under hypoxic conditions to reduce oxygen demand and prevent cellular damage [76]

J.SeyfriedT

For example, VIR-2218, a GalNAc-siRNA conjugate that targets HBV, uses enhanced stability chemistry plus technology to stabilize the siRNA in vivo and reduce off-target effects