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Freezing can cause the vitamins (especially riboflavin and perhaps dexpanthenol) to precipitate or the solution to phase-separate

To get the best results, stick to the recommended doses and ways to get them

McIlwain, H., Stanley, D

Important Notice These products are: Not approved for human consumption Not approved for diagnostic or therapeutic use Not intended for medical application Intended strictly for controlled laboratory research Researchers should use laboratory materials only within lawful research environments

Kannt et al., 2015

While the overall safety profile is favorable, no injectable treatment is entirely without risk, and patients deserve full disclosure before consenting to the procedure