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Chromatographic and mass spectrometric parameters of this screening method are summarized in the Table 1

OSteen S, Comstock ML, Orozco JJ, Hamlin DK, Wilbur DS, Jones JC, et al

Chlopicki S, Swies J, Mogielnicki A, Buczko W, Bartus M, Lomnicka M, Adamus J, Gebicki J (2007) 1-Methylnicotinamide (MNA), a primary metabolite of nicotinamide, exerts anti-thrombotic activity mediated by a cyclooxygenase-2/prostacyclin pathway

(Lond) 19, 20

Under normal conditions, NNMT activity can consume substantial amounts of both nicotinamide and SAM, particularly in metabolically active tissues or during periods of metabolic stress