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The differences between CGRP medications There are two types of CGRP inhibitors: CGRP monoclonal antibodies (MABs), which are used for migraine prevention: Erenumab (Aimovig) Fremanezumab (Ajovy) Galcanezumab (Emgality) Eptinezumab (Vyepti) CGRP receptor antagonists (gepants), which are used both as abortive and/or preventive migraine medications Rimegepant (Nurtec): Acute or preventive treatment of episodic migraine Atogepant (Aquipta): Preventive treatment - TGA approved but not yet available in Australia Ubrogepant (Ubrelvy): Acute treatment - not yet available in Australia Zavegepant (Zavzpret): Acute treatment - not yet available in Australia Like most new medicines, accessing the CGRP treatments privately is expensive

PI3K, phosphatidylinositol 3-kinase

10.1038/s41467-023-42056-1 59 ElahiF

PubMed PMID: 27398013

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