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Glutathione Peroxidase 4-catalyzed Reduction of Lipid Hydroperoxides in Membranes: The Polar Head of Membrane Phospholipids Binds the Enzyme and Addresses the Fatty Acid Hydroperoxide Group toward the Redox Center

Satoru Nishizawa, et al

31 However, despite promising results from preclinical studies, including the targeting of mast cells through inhibition of the c-Kit RTK, 32 when inhibitors targeting various relevant RTKs were tested in clinical trials using sorafenib for patients with OPG 33 (NCT01338857) or imatinib for pNF 34 (NCT01673009) and MPNST 35 (NCT00031915), disappointingly, they largely lacked efficacy at reducing tumour burden

Sensitivity of the liver cancer HepG2 cells to paracetamol, BSO and their combination

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