These commenters stated that using ADI to determine HEBA eligibility and amounts could ensure more precise targeting of resources to areas most in need, and that, while person-level measures of social vulnerability are the gold standard, validated geographic indices such as the ADI are useful proxies. One commenter described the ADI as a crucial metric for identifying underserved communities. A few commenters recognized the shortcomings of currently available metrics, including ADI, for identifying beneficiaries from underserved communities but noted that using all available data on social risk for purposes of determining HEBA eligibility and amounts will expand the HEBA's ability to address issues [related to providing care for higher-risk beneficiaries]. Many other commenters suggested considering metrics such as Medicare enrollment due to disability in combination with the ADI and the proportion of the ACO's assigned beneficiaries who are enrolled in the Medicare Part D LIS or dually eligible for Medicare and Medicaid for the purposes of determining eligibility for and the amount of any HEBA
A sudden change could lead to unwanted health complications
CMS may recalculate a rebate amount and provide the manufacturer of a Part B rebatable drug a report with a reconciled rebate amount when: (i) CMS identifies an agency error in the information specified in paragraphs (c) and (d)(1) of this section, including reporting system or coding errors, not later than 3 years from the date of receipt by a manufacturer of a reconciled rebate amount for the applicable calendar quarter
It upregulates heme oxygenase-1, reducing oxidative stress that impairs healing
This leads to a situation where white blood cells such as macrophages continue producing cytokines and, while continuing their attack on foreign microbes, release reactive oxygen species (ROS) and other chemicals that harm normal tissue
Key Summary There is no strong clinical evidence that properly dosed oral glutathione causes kidney damage in healthy individuals
