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& Espin, J

A recent study adds another layer of complexity by the Wnt signaling via crosstalk with various chromatin modifiers

Moreover, it has been suggested that starvation reduces liver glycogen storage and hence reduces UGT conjugative ability leading to a greater fraction of the dose being oxidised to NAPQI [77]

Toxins can wreak havoc on the skin, so detoxification is crucial

However, the field must confront the limitations of reductionist models by embracing systems-level approaches that account for the biological and environmental complexity of AUD and depression