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For instance, activation of NRF2 promotes ROS clearance in drug-resistant liver cancer cell lines [31]

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Your body usually has plenty of glycine and glutamic acid, but cysteine is harder to come by

Methods Enzymol 401:18 Margis R, Dunand C, Teixeira FK, Margis-Pinheiro M (2008) Glutathione peroxidase family - an evolutionary overview

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Mechanistically, GLPs exert renoprotective effects by suppressing the PI3K/Akt/mTOR signaling cascade, promoting autophagicevidenced by increased Beclin-1 expression and LC3-II/LC3-I ratio, along with decreased p62 accumulationwhile simultaneously attenuating apoptotic activity (reducing caspase-3 and caspase-9 levels) and dampening pro-inflammatory responses (lowering IL-6, IL-1, and TNF-)