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Thirty-seven cases (26 male patients and 11 female patients) of vitiligo associated with biologic drug use have been reported

This finding is in line with results of Simonsen et al

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The Pro-Gly-Pro tail is chemically simple but functionally revolutionary: it blocks the carboxypeptidases that would otherwise destroy the peptide and allows enough residence time for nose-to-brain transport, receptor engagement, and downstream gene-expression effects

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Pyrimethamine is anti-parasitic medicine used in cats to treat protozoa related disease