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Cell culture studies have shown that phenobarbital (PB), phenytoin (PHT), primidone (PRM), carbamazepine (CBZ), oxcarbazepine and felbamate induce CYP3A4 expression, whereas ethosuximide (ETHS), valproic acid (VPA), and lamotrigine (LTG) have no effect on CYP3A4 activity 60, 61

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35 In practice, in the context of depression, the monoamine hypothesis is primarily a serotonin hypothesis since it is to this neurotransmitter that depression and its symptoms are most commonly attributed