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Intriguingly, both regulatory pathways are not responsive to iron directly, but instead react to Fe-S cluster levels 133

Histologically, IPF is defined by the usual interstitial pneumonia (UIP) pattern, characterized by patchy fibrosis, fibroblastic foci, and honeycombing ( 1.3 Ferroptosis and IPF Ferroptosis, a unique form of cell death derived by iron overload and lipid peroxidation, has emerged as a critical contributor to oxidative stress and chronic inflammation in IPF

Probiotics Probiotics are live microorganisms that can enhance gut health and reduce inflammation [81]

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