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Immunomodulatory nanoparticles (IMPs) are highly negatively charged, 500 nm-diameter particles composed of the biodegradable biopolymer carboxylated poly(lactic-co-glycolic) acid (PLGA-COOH) (Sharma et al., 2020

Moreover, another study by Sagrillo-Fagundes and his group found that melatonin significantly regulated autophagy and inflammation in primary trophoblast cells that were exposed to a hypoxic/reoxygenation environment, mimicking preeclamptic pregnancy, thus reducing apoptosis in these cells

doi: Emmez H, Yildirim Z, Kale A, Tnge M, Durda E, Brcek A, Uanku LN, Doulu F, Kili N, Baykaner MK (2010) Anti-apoptotic and neuroprotective effects of alpha-lipoic acid on spinal cord ischemiareperfusion injury in rabbits

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Timing & therapeutic window Ferroptotic cell death in acute cardiac injury occurs within a narrow time frame, making the timing of intervention critical

Increasing growth hormone and IGF-1 levels may carry potential risks, including worsening insulin resistance in some individuals and, theoretically, stimulating the growth of existing cancers