Emerging evidence suggests that Vitamin D acts not only as a classical micronutrient for skin homeostasis, but also as an environment-responsive signaling regulator, orchestrating adaptive remodeling to both exogenous insults and intrinsic aging cues through a complex VDR-dependent transcriptional network
Collagen: The Building Block of Youthful Resilience Collagen is one of the most critical proteins for maintaining strength, flexibility, and resilience as we age
Pitzler C
It upregulates genes involved in collagen synthesis (COL1A1, COL3A1, COL5A1), extracellular matrix remodeling (decorin, fibromodulin), and antioxidant defense (superoxide dismutase, glutathione peroxidase) while simultaneously suppressing genes associated with inflammation (IL-6, TNF-alpha), fibrinogen production, and tissue destruction (several MMPs)
The severity of these effects is influenced by genetic predisposition, individual metabolic differences, and variations in drug pharmacokinetics (Rivetti et al
The combination of (-)-Vestitol and Salviolone synergistically regulated more genes and pathways related to AD To elucidate the underlying MOA for the synergistic effects of the combination of (-)-Vestitol and Salviolone, we performed RNA-seq analysis on the cortex of the WT, control, (-)-Vestitol, Salviolone, and combination groups
