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Additionally, mitochondria are able to activate different intracellular signaling pathways necessary to defend the host against pathogens such as the mitochondrial anti-viral signaling (MAVS) and activation of the nucleotide-binding oligomerization domain (NOD)-, leucine-rich repeat (LRR)- and pyrin domain-containing protein 3 (NLRP3) inflammasome by mitochondrial DNA (mtDNA) (Zhong et al., 2018)

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So the biological rationale is real and multi-pronged