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Cell density could also not account for the observed metabolic heterogeneity (Extended Data Fig

Biomed Res Int 2014:472459

Additionally, zinc acts as a cofactor for superoxide dismutase (Cu/Zn SOD) and regulates the expression of metallothioneins, which scavenge ROS (367)

However, the presence of DTT on C41 and C108 might explain why C110 is the only available cysteine to support dimerization, if the former are naturally protected by GSH in vivo