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MM was involved in conducting the phase 1 and 2 portions of this study, in performing the plasma L-citrulline and L-arginine analyses in phase 3, and was involved in manuscript preparation

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Additionally, the hyperactivation of PARP-1 depletes cellular NAD + pools, which in turn suppresses NAD + -dependent SIRT1 and indirectly impairs autophagic flux ( + reserves, thereby reducing the activity of the NAD + -dependent deacetylase SIRT1 and ultimately lowering autophagy levels (Zhang et al., 2023

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