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In mice, overexpression of hepatocyte TAZ is sufficient to drive NASH progression, whereas TAZ silencing attenuates inflammation and fibrosis (149)

10.1017/S0033291721005092 497 YassinL

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Proceedings of the National Academy of Sciences, 2007, 104(36): 14342-7

Changes in dynamics reduce mitophagy efficiency, while ineffective mitophagy allows dysfunctional mitochondria to build up and disturb normal processes